Abstract: Experience of stress is unavoidable during the development of children with the appropriate stress facilitating the growth of children whereas excessive stress will induce the physiological change causing too sensitive stress response system and disordering hormone secretion, which effects their brain development, that is toxic stress. It is important to understand the effects of early life toxic stress on the development of children from the biological perspectives, and some constructive suggestions are put forward to the caregiver, children, and educational; policy makers.

Key words: children, toxic stress, physiological change, caregiver, education regulation